Acid-C1-PEG5-Boc

SKU: orb1307574

Description

Acid-C1-PEG5-Boc is a Boc-protected linker featuring a PEG spacer and a terminal carboxylic acid, designed for synthesizing PROTAC molecules. This reagent is utilized in chemical biology and drug discovery research to develop bifunctional degraders for target validation in both cellular and preclinical studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2304558-22-1
• MW: 380.43
• Purity: 99.89% (May vary between batches)
• Formula: C₁₇H₃₂O₉
• SMILES: O(C(CCOCCOCCOCCOCCOCC(O)=O)=O)C(C)(C)C
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs are bifunctional molecules comprised of two distinct ligands linked together; one ligand binds to an E3 ubiquitin ligase, while the other targets a specific protein. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PROTAC Linker, PROTAC Linkers, PROTACLinker, inhibit, PEGs, Inhibitor, Acid-C1-PEG5-Boc, AcidC1PEG5Boc, Acid-C-1-PEG5-Boc, Acid C1 PEG5 Boc

Compound Identifiers

PubChem CID

137700743