AChE/BChE/MAO-B-IN-1

SKU: orb1689142

Description

This small molecule is a reversible, non-time-dependent inhibitor of human AChE, BChE, and MAO-B enzymes with respective IC50 values of 7.31, 0.56, and 26.1 μM. It is BBB-permeable, demonstrates neuroprotective properties in vitro, and shows low cytotoxicity, making it a candidate for research in neurodegenerative disease models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2416910-82-0
• MW: 324.42
• Purity: 99.69% (May vary between batches)
• Formula: C₂₀H₂₄N₂O₂
• SMILES: C(N1CCC(COC(NC2=CC=CC=C2)=O)CC1)C3=CC=CC=C3
• Target: MAO,Monoamine Oxidase,Cholinesterase (ChE)
• Solubility: DMSO:27.5 mg/mL (84.77 mM)

Bioactivity

• Target IC50:
  BChE:0.56 μM|MAO-B:26.1 μM|AChE:7.31 μM
• In Vitro:
  AChE/BChE/MAO-B-IN-1 inhibits amyloid β 1-42 (Aβ 1-42)-induced neuronal cell death.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAO-B, BChE, AChE

Compound Identifiers

PubChem CID

162662555