Acetazolamide sodium

SKU: orb1909019

Description

Acetazolamide sodium is a selective carbonic anhydrase IX (CAIX) inhibitor used in research for its diuretic and antihypertensive properties. It is applied in studies related to glaucoma, epilepsy, and tumor hypoxia, with utility in both in vitro enzymatic assays and in vivo models for conditions like edema and altitude sickness.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1424-27-7
• MW: 244.23
• Purity: 99.71% (May vary between batches)
• Formula: C₄H₅N₄NaO₃S₂
• SMILES: O=C(C)NC1=NN=C(S(=O)([NH-])=O)S1.[Na+]
• Target: Autophagy,Antibacterial,Carbonic Anhydrase
• Solubility: H2O:80 mg/mL (327.56 mM);DMSO:80 mg/mL (327.56 mM)

Bioactivity

• In Vivo:
  In preclinical xenograft models, treatment with AZ (40 mg/kg), MS-275 (20 mg/kg), and AZ + MS-275 (40 + 20 mg/kg) for 14 days significantly inhibited tumor growth in vivo. The expression of HIF-1α and CAIX markedly decreased, while apoptosis in NB xenograft cells of SH-SY5Y significantly increased.
• In Vitro:
  The combination of Acetazolamide sodium (0-160 μM) with MS-275 (0.75 μM) exhibited dose-dependent inhibition of growth, induced cell cycle arrest and apoptosis, and reduced migration ability in NB cell line SH-SY5Y.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CarbonicAnhydrase, Carbonic Anhydrase, Carbonic anhydrase IX, OT-302 sodium

Compound Identifiers

PubChem CID

13290219