Acebilustat

SKU: orb1303856

Description

Acebilustat

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 943764-99-6
• MW: 481.54
• Purity: 99.47%
• Formula: C₂₉H₂₇N₃O₄
• SMILES: [H][C@]12CN(Cc3ccc(cc3)C(O)=O)[C@]([H])(CN1Cc1ccc(Oc3ccc(cc3)-c3ncco3)cc1)C2
• Target: LTR,Aminopeptidase
• Solubility: Methanol:32 mg/mL (66.45 mM);DMSO:60 mg/mL (124.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.08 mM)

Bioactivity

• In Vitro:
  Acebilustat, a potent leukotriene A4 hydrolase (LTA4H) inhibitor, demonstrated safety and tolerability in a phase 1 trial. Currently under development as an anti-inflammatory medication, it targets CF among other diseases by inhibiting LTA4H, the crucial enzyme in leukotriene B4 (LTB4) production. LTB4 acts as a powerful chemoattractant and activator for inflammatory immune cells, such as neutrophils, thus Acebilustat's mechanism holds promise for mitigating inflammatory responses.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CTX 4430, CTX4430, CTX-4430, Acebilustat, Aminopeptidase, inhibit, LTB4, Inhibitor

Compound Identifiers

PubChem CID

68488178