ABT-737-d8

SKU: orb3138609

Description

ABT 737-d8 is the deuterated form of ABT-737, a BH3 mimetic and potent inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM respectively. ABT-737 disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent and BIM-independent manner. Additionally, ABT-737 induces autophagy and shows potential for research in acute myeloid leukemia (AML).

Key Properties

• CAS Number: 1217686-68-4
• MW: 821.48
• Formula: C₄₂H₄₅ClN₆O₅S₂
• SMILES: ClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H]
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others