Abivertinib HCl

SKU: orb1739034

Description

Abivertinib (AC0010) is a third-generation EGFR and BTK inhibitor with demonstrated efficacy in research models of acute myeloid leukemia (AML), particularly against FLT3-ITD mutant cells. It shows superior sensitivity compared to ibrutinib in vitro, inducing apoptosis and cell cycle arrest, and holds promise for combination therapies in oncology research.

Key Properties

• CAS Number: 1557268-90-2
• MW: 560.4554
• Formula: C₂₆H₂₈Cl₂FN₇O₂
• SMILES: Cl.Cl.CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1F
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171360836