Abeprazan hydrochloride

SKU: orb1710507

Description

Abeprazan hydrochloride (Fexuprazan hydrochloride) is an orally active, reversible potassium-competitive acid blocker (P-CAB) that inhibits gastric H+/K+-ATPase. It is used in research for investigating gastric acid-related disorders like GERD and peptic ulcers, with applications in both in vitro mechanistic studies and in vivo pharmacological models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1902954-87-3
• MW: 446.87
• Purity: 98.62% (May vary between batches)
• Formula: C₁₉H₁₈ClF₃N₂O₃S
• SMILES: Cl.CNCc1cn(c(c1OC)-c1ccc(F)cc1F)S(=O)(=O)c1cccc(F)c1
• Target: Proton pump
• Solubility: DMSO:40 mg/mL (89.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM)

Bioactivity

• In Vivo:
  Abeprazan hydrochloride effectively suppresses acid secretion in a dose-responsive manner, demonstrating equal or superior efficacy to vonoprazan, an established P-CAB, across multiple in vivo studies including pylorus-ligated rats, lumen-perfused rat models, and Heidenhain pouch dog models.
• In Vitro:
  The mechanism of action of Abeprazan hydrochloride involves reversible binding to H+, K+-ATPase, and, unlike PPIs, it does not require an acidic environment for activation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abeprazan Hydrochloride, DWP 14012 Hydrochloride, DWP14012 Hydrochloride, DWP14012 hydrochloride, DWP-14012 Hydrochloride, Fexuprazan Hydrochloride, Fexuprazan hydrochloride, Protonpump, Proton pump

Compound Identifiers

PubChem CID

130454904