AAF-CMK (trifluoroacetate salt)

SKU: orb1693827

Description

Tripeptidyl peptidase II (TPPII) is a subtilisin-type serine peptidase that cleaves tripeptides from oligopeptide N-termini. The irreversible inhibitor AAF-CMK (10-100 µM) selectively targets TPPII without affecting proteasomal chymotrypsin-like activity, though it also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase at 50 µM. This compound is a valuable tool for studying intracellular protein degradation pathways in both cellular and biochemical assays.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 184901-82-4
• MW: 453.84
• Formula: C₁₈H₂₃ClF₃N₃O₅
• SMILES: OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)CCl
• Target: Proteasome,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171360480