AA92593

SKU: orb1298827

Description

AA92593 is a selective melanopsin (OPN4) inhibitor used in research. It is a valuable tool for studying non-image-forming visual responses, such as circadian photoentrainment and the pupillary light reflex, in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 457961-34-1
• MW: 269.36
• Purity: 99.87% (May vary between batches)
• Formula: C₁₃H₁₉NO₃S
• SMILES: COc1ccc(cc1C)S(=O)(=O)N1CCCCC1
• Target: Others
• Solubility: DMSO:22.5 mg/mL (83.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.43 mM)

Bioactivity

• In Vitro:
  The involvement of melanopsin in the regulation of melatonin was also determined by using a specific inhibitor AA92593 and by inhibiting melanopsin-induced phospholipase C activation. Under this situation neither AANAT nor melatonin levels changed under light conditions (n = 4, ***p < 0.001). The discovery of melanopsin in the lens opens the possibility of regulating melatonin synthesis with the corresponding implication as an antioxidant substance.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OPN4, inhibit, Inhibitor, Melanoma, Melanopsin, melanopsin, CHO, AA 92593, AA92593, AA-92593, Per1, α-MSH

Compound Identifiers

PubChem CID

847007