A2AR modulator-1

SKU: orb3135016

Description

A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.

Key Properties

• CAS Number: 3007566-23-3
• MW: 380.45
• Formula: C₂₃H₂₀N₆
• SMILES: N#CC1=C(N=C(C(C#N)=C1C=2C=CC=C(C2)C3=CN=CC=C3)N4CCCCC4)N
• Target: Adenosine Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Adenosine Receptor