A11

SKU: orb2563656

Description

A11 is an ANXA1-derived peptide that disrupts the ANXA1-EphA2 interaction, promoting Cbl-mediated EphA2 ubiquitination, internalization, and degradation. This mechanism inhibits proliferation, migration, invasion, and angiogenesis in nasopharyngeal carcinoma (NPC) cells, supporting its use in oncological research targeting the EphA2 signaling pathway.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: Ephrin Receptor,Annexin A
• CAS Number: 2412926-29-3
• MW: 1225.35
• Formula: C₅₃H₈₈N₁₄O₁₉
• SMILES: [C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CO)=O)CO)=O)CCCCN)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)NC([C@H](CCC(O)=O)N)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171714357