8-Azahypoxanthine

SKU: orb1306752

Description

8-Azahypoxanthine is a purine analog that acts as an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This mechanism underlies its studied antimalarial activity, as it disrupts purine salvage in Plasmodium parasites. It serves as a research tool for investigating nucleotide metabolism in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2683-90-1
• MW: 137.1
• Formula: C₄H₃N₅O
• SMILES: O=C1N=CNC2=NNN=C12
• Target: Nucleoside Antimetabolite/Analog
• Solubility: DMSO:55 mg/mL (401.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.59 mM)

Bioactivity

• In Vitro:
  8-Azahypoxanthine has a slight radiosensitizing effect on haemopoietic stem cells and leucotic cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC22709, NSC-22709, NSC 22709, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Nucleoside Antimetabolite, 8 Azahypoxanthine, 8Azahypoxanthine, 8-Azahypoxanthine, Analog

Compound Identifiers

PubChem CID

135410720