6-O-desmethyl Donepezil

SKU: orb1692956

Description

6-O-desmethyl Donepezil is the primary active metabolite of donepezil, generated via CYP2D6 metabolism. This compound acts as an acetylcholinesterase inhibitor and also blocks hERG potassium channels (IC50 ~1.5 μM), making it a relevant tool for neuropharmacology and cardiac safety research in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	120013-56-1
MW	365.47
Formula	C₂₃H₂₇NO₃
SMILES	O=C1C2=CC(O)=C(OC)C=C2CC1CC3CCN(CC=4C=CC=CC4)CC3
Target	Others,Drug Metabolite,Potassium Channel

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

14553555 ↗

Key Properties

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No computed properties available.

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