6-Mercaptopurine

SKU: orb1311031

Description

6-Mercaptopurine (6-MP) is a purine analog antimetabolite used in research for its antineoplastic and immunosuppressive properties. It inhibits DNA/RNA synthesis and is widely applied in leukemia research models, both in vitro and in vivo, to study mechanisms of cytotoxicity and remission maintenance.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 50-44-2
• MW: 152.18
• Purity: 99.94% (May vary between batches)
• Formula: C₅H₄N₄S
• SMILES: Sc1ncnc2nc[nH]c12
• Target: Dehydrogenase,Autophagy,Endogenous Metabolite,Nucleoside Antimetabolite/Analog
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:41.67 mg/mL (273.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.57 mM)

Bioactivity

• In Vivo:
  Phosphoribosyl pyrophosphate amidotransferase acts as the rate-limiting enzyme in purine biosynthesis, affecting the synthesis and function of RNA and DNA. Mercaptopurine inhibits this enzyme, thereby hindering purine nucleoside and its metabolism, which interferes with nucleotide interconversion and glycoprotein synthesis.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

6 Mercaptopurine, 6-MP, 6Mercaptopurine, 6-Mercaptopurine, Autophagy, Analog, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, IMPDH, Inhibitor, inhibit, Mercaptopurine, HPRT, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

667490