6-Mercaptopurine hydrate

SKU: orb1306123

Description

6-Mercaptopurine monohydrate is a nucleoside metabolic inhibitor that disrupts purine synthesis, thereby impeding nucleic acid production. It is widely used in leukemia research, both in vitro and in vivo, for studying remission maintenance and combination therapies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 6112-76-1
• MW: 170.19
• Purity: 99.14%
• Formula: C₅H₆N₄OS
• SMILES: c1nc2c([nH]1)c(=S)nc[nH]2.O
• Target: Nucleoside Antimetabolite/Analog,DNA/RNA Synthesis
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.88 mM);DMSO:4.23 mg/mL (24.85 mM)

Bioactivity

• In Vitro:
  Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, DNA synthesis, 6 Mercaptopurine hydrate, 6-MP, 6-Mercaptopurine, 6-Mercaptopurine (6-MP), 6-Mercaptopurine (6-MP) Monohydrate, 6Mercaptopurine hydrate, 6-Mercaptopurine Hydrate, 6-Mercaptopurine Monohydrate, 6-Mercaptopurine monohydrate, Analog, Inhibitor, Mercaptopurine, inhibit, Nucleoside Antimetabolite, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, PRPP Amidotransferase, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

2724350