6-(Dimethylamino)purine

SKU: orb1685492

Description

6-(Dimethylamino)purine is a cell-permeable inhibitor of serine/threonine kinases, including cyclin-dependent kinases (CDKs). It is utilized in vitro to study cell cycle regulation and has been applied in vivo to investigate developmental processes in various model organisms.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 938-55-6
• MW: 163.18
• Purity: 99.01% (May vary between batches)
• Formula: C₇H₉N₅
• SMILES: CN(C)c1ncnc2nc[nH]c12
• Target: DNA/RNA Synthesis,CDK,Serine/threonin kinase,Apoptosis
• Solubility: DMSO:32 mg/mL (196.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.26 mM)

Bioactivity

• In Vitro:
  The apoptosis was induced by 6-dimethylaminopurine(6-DMAP) in a dose- and time-dependent manner and treatment for 16 h at a concentration of 5 mM induced apparent DNA fragmentation, phosphatidylserine externalization and lowering of the mitochondrial membrane potential, which are typical markers of apoptosis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK, Cyclin dependent kinase, 6-Dimethylaminopurine, 6(Dimethylamino)purine, 6-(Dimethylamino)purine, 6 (Dimethylamino)purine, N,N-Dimethyladenine, Inhibitor, inhibit, threoninkinase, threonin kinase, Serinekinase, Serine kinase, serine threonine protein kinase

Compound Identifiers

PubChem CID

3134