5,6-Dihydrouridine

SKU: orb1706291

Description

5,6-Dihydrouridine is a conserved tRNA modification present in the D-loop across Eukaryota, Bacteria, and some Archaea. This small molecule is used in research to study RNA structure, modification enzymes, and translational regulation in both in vitro biochemical assays and cellular studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 5627-05-4
• MW: 246.22
• Purity: 99.57%
• Formula: C₉H₁₄N₂O₆
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O
• Target: Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM);DMSO:32.1 mg/mL (130.37 mM);H2O:90 mg/mL (365.53 mM)

Bioactivity

• Target IC50:
  Cytidine deaminase (E. coli):3.4 μM(Ki)
• In Vitro:
  5,6-Dihydrouridine (Dihydrouridine) is a posttranscriptionally modified nucleoside, resulting from the reduction of uridine (U) and can be further altered to 5-methyldihydrouridine (m5D). It is identified in six positions within the 'D-loop' of tRNA (16, 17, 20a, 20b) and in position 47 of the variable loop.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5,6 Dihydrouridine, 5,6Dihydrouridine, 5,6-Dihydrouridine, Human Endogenous Metabolite, Endogenous Metabolite, EndogenousMetabolite

Compound Identifiers

PubChem CID

94312