5-OHdU

SKU: orb1307118

Description

5-Hydroxy-2'-deoxyuridine

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 5168-36-5
• MW: 244.2
• Purity: 98.32% (May vary between batches)
• Formula: C₉H₁₂N₂O₆
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(O)c(=O)[nH]c1=O
• Target: Endogenous Metabolite|||Nucleoside Antimetabolite/Analog
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.19 mM);DMSO:30 mg/mL (122.85 mM)

Bioactivity

• In Vitro:
  Translesion synthesis past 5-OHdU in 18- and 45-member oligodeoxyribonucleotides occurred, but pauses both opposite, and one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 5-OHdU in the template is sequence context-dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 5-OHdU. However, in a second sequence context, dC is the predominant base incorporated opposite 5-OHdU. In that same sequence context, dC is also the predominant nucleotide incorporated opposite 5-OHdU.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human Endogenous Metabolite, EndogenousMetabolite, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, Nucleoside Antimetabolite, Endogenous Metabolite, 5-OHdU, Analog

Compound Identifiers

PubChem CID

96622