5-O-Demethylnobiletin

SKU: orb1301558

Description

5-O-Demethylnobiletin

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2174-59-6
• MW: 388.37
• Purity: 99.83%
• Formula: C₂₀H₂₀O₈
• SMILES: COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(OC)c(OC)c2o1
• Target: Lipoxygenase,Leukotriene Receptor
• Solubility: DMSO:3.89 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM)

Bioactivity

• Target IC50:
  LTC4:0.35 μM (IC50)|5-LOX:0.1 μM (IC50)
• In Vivo:
  5-O-Demethylnobiletinreduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA -induced oedema in mouse paws.The flavone inhibited leukotriene B formation in rat neutrophils and elastase release in human neutrophils, but did not reduce the expression of cyclooxygenase-2 (COX-2) in murine RAW 264.7 macrophages.These experimental results suggest that 5-O-Demethylnobiletinmay actthrough a direct inhibition of 5-LOX, without affecting the expression of COX-2.
• In Vitro:
  5-DEMETHYLNOBILETIN promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5 O Demethylnobiletin, 5-DEMETHYLNOBILETIN, 5ODemethylnobiletin, 5-O-Demethylnobiletin, Leukotriene Receptor, LeukotrieneReceptor, LOX, Lipoxygenase, Inhibitor, inhibit

Compound Identifiers

PubChem CID

358832