5-hydroxytryptophan

SKU: orb1304632

Description

5-Hydroxytryptophan (5-HTP) is a tryptophan metabolite that serves as the immediate biosynthetic precursor to serotonin. It is a substrate for aromatic L-amino acid decarboxylase and is widely used in neuroscience research to study serotonin pathways, including the induction of depression models in vivo and enzymatic assays in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 56-69-9
• MW: 220.22
• Purity: 100.00%
• Formula: C₁₁H₁₂N₂O₃
• SMILES: NC(CC1=CNC2=CC=C(O)C=C12)C(O)=O
• Target: Endogenous Metabolite
• Solubility: H2O:4 mg/mL (18.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.08 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:250 mg/mL (1135.23 mM)

Bioactivity

• In Vivo:
  5-Hydroxytryptophan is an intermediate in the biosynthesis of serotonin from the essential amino acid L-tryptophan, which can easily cross the blood-brain barrier and effectively increase the synthesis of serotonin within the central nervous system. It has been shown to improve conditions such as depression, chronic headaches, and insomnia.
• In Vitro:
  5-Hydroxytryptophan exhibits toxicity in mice with an LD50 of 1800 mg/kg. In rats, it demonstrates effects at a dosage of 300 mg/kg when administered intragastrically (i.g.).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, EndogenousMetabolite, inhibit, NSC 92523, NSC92523, NSC-92523, 114-03-4, 5hydroxytryptophan, 5-Hydroxytryptophan, 5-hydroxytryptophan, 5-HTP, 5 hydroxytryptophan, Endogenous Metabolite

Compound Identifiers

PubChem CID

144