5α-Hydroxycostic acid

SKU: orb1683418

Description

5α-Hydroxycostic acid is a sesquiterpene that suppresses choroidal neovascularization in vivo by targeting VEGF/VEGFR and Ang2/Tie2 pathways. It also demonstrates anti-angiogenic and anti-inflammatory activity in human breast cancer cell models, supporting its utility in oncology and ophthalmology research.

Research Area

Cardiovascular Research, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 132185-83-2
• MW: 250.33
• Formula: C₁₅H₂₂O₃
• SMILES: C[C@]12CCCC(=C)[C@@]1(O)C[C@@H](CC2)C(=C)C(O)=O
• Target: NOS|||Akt|||FAK|||ERK|||Phospholipase|||Src

Bioactivity

• In Vitro:
  Methods: RCSEC cells were treated with 5α-Hydroxycostic acid (25, 50, 100 μM, 48 hours) and the inducing factor VEGF164 (30 μM) was added. Cell viability was measured by CCK8. Results: The drug had a significant effect on cell viability at concentrations above 100 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FAK, ERK, PLCγ, NOS, 5 alpha-Hydroxycostic acid, 5αHydroxycostic acid, 5α-Hydroxycostic acid, 5α Hydroxycostic acid, 5alpha-Hydroxycostic acid, 5a-Hydroxycostic acid, AKT, Src, VEGF

Compound Identifiers

PubChem CID

14705651