5-Heneicosylresorcinol

SKU: orb1683443

Description

This research compound, 5-heneicosylresorcinol, exhibits anti-allergic activity by inhibiting β-hexosaminidase release in RBL-2H3 cells and anti-adipogenic effects by reducing triglyceride accumulation in 3T3-L1 cells. It also demonstrates nematicidal activity against P. redivivus, C. elegans, and B. xylophilus.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 70110-59-7
• MW: 404.67
• Formula: C₂₇H₄₈O₂
• SMILES: CCCCCCCCCCCCCCCCCCCCCc1cc(O)cc(O)c1
• Target: NADPH-oxidase|||Antifection

Bioactivity

• In Vitro:
  Alkylresorcinols are phenolic lipids present at levels of 0.03-0.15% in wheat and rye grains and almost 10 times higher in respective bran products. Despite numerous studies on the influence of dietary fibers on the regulation of energy metabolism, this issue still remains controversial. METHODS AND RESULTS: The objective of our current studies was to investigate whether 5-n-alk(en)ylresorcinols, natural phenolic components of high fiber human diets, may be considered as natural regulators of excessive fat accumulation. Our studies revealed that 5-n-alk(en)ylresorcinols isolated from wheat and rye bran inhibit glycerol-3-phosphate dehydrogenase, the key enzyme in triglyceride synthesis in adipocytes, specifically and effectively. Further in vitro studies showed that these compounds also prevent triglyceride accumulation in 3T3-L1 cells. CONCLUSIONS: The most effective compound in both systems was 5-n-heneicosylresorcinol(5-Heneicosylresorcinol). The results indicate that the potential to prevent triglyceride accumulation increases with the hydrophobicity of the phenolic inhibitor.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5 Heneicosylresorcinol, 5Heneicosylresorcinol, 5-Heneicosylresorcinol, Antifection, antifungal, cereals, inhibit, Inhibitor, microscale amended medium assay, NADPH-oxidase, NADPHoxidase, Fungal, Fusarium oxysporum, supervised metabolite profiling

Compound Identifiers

PubChem CID

155461