5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

SKU: orb1297840

Description

Antileishmanial agent-2 is a potent 3-bromo-isoxazoline compound exhibiting dual antiparasitic activity. It inhibits Plasmodium falciparum (D10, W2) and Leishmania spp. (L. infantum, L. tropica) promastigotes in vitro with low micromolar IC50 values, making it a candidate for antimalarial and antileishmanial drug discovery research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2863687-18-5
• MW: 350.21
• Purity: 99.58%
• Formula: C₁₅H₁₆BrN₃O₂
• SMILES: C(C)(C)(C)C1=CC=C(C=2N=C(ON2)C3ONC(Br)=C3)C=C1
• Target: Parasite
• Solubility: DMSO:65 mg/mL (185.6 mM)

Bioactivity

• Target IC50:
  P. falciparum:35 nM(D10 strains)|P. falciparum:58 nM(W2 strains)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5(3bromo4,5dihydroisoxazol5yl)3(4(tertbutyl)phenyl)1,2,4oxadiazole, 5 (3 bromo 4,5 dihydroisoxazol 5 yl) 3 (4 (tert butyl)phenyl) 1,2,4 oxadiazole, P. falciparum

Compound Identifiers

PubChem CID

171361432