4,9-Anhydrotetrodotoxin

• Catalog Number: orb1693171
• Category: Small Molecules
• Description: 4,9-Anhydrotetrodotoxin
• Purity: 98.00%
• MW: 301.25
• Biological Activity: 4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and > 30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
• CAS Number: 13072-89-4
• Formula: C₁₁H₁₅N₃O₇
• SMILES: O[C@H]1[C@]23[C@@]4([C@@]5([C@](CO)(O)[C@]1(O[C@](O)([C@]2(O[C@@]4(N=C(N)N3)[H])[H])O5)[H])[H])[H]
• Storage: -20°C
• Note: For research use only