4-P-PDOT

SKU: orb1940913

Description

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

Key Properties

• CAS Number: 134865-74-0
• MW: 279.38
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁NO
• SMILES: CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3
• Target: MT2 receptor
• Solubility: DMSO:41.67 mg/mL (149.15 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Klotho mutant mice treatment with Melatonin. Dosage: 0.5 mg/kg or 1.0 mg/kg. Administration: Intravenous injection. Result: Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice.
• In Vitro:
  Cell Viability Assay Cell line: HT-29 and HeLa cells. Concentration: 50 μM. Incubation time: 30 min. Result: Produced a negligible effect on cell viability induced by melatonin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-phenyl-2- propionamidotetralin

Quick Database Links

Gene Symbol

MT2 receptor