4-Methylamino antipyrine

SKU: orb1310046

Description

4-Methylamino antipyrine

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 519-98-2
• MW: 217.27
• Purity: 99.87%
• Formula: C₁₂H₁₅N₃O
• SMILES: CNc1c(C)n(C)n(-c2ccccc2)c1=O
• Target: COX,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.6 mM);DMSO:2.78 mg/mL (12.8 mM)

Bioactivity

• In Vivo:
  Eight healthy Male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentration are quantitatively detectable from 0.25 to 48 h the average maximum concentration of 4-Methylamino antipyrine is 47.59 mg mL the average half-lives is 8.57 h for 4-Methylamino antipyrine.
• In Vitro:
  At room temperature and in an atmosphere with oxygen, Metamizole is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yfield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine.

Storage & Handling

• Storage: keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, nonopioid, NSAID, metabolite, Metamizole, Inhibitor, 4Methylamino antipyrine, 4-Methylamino antipyrine, 4 Methylamino antipyrine, analgesic, anti-inflammatory, antipyretic, Drug Metabolite, DrugMetabolite, Cyclooxygenase, COX

Compound Identifiers

PubChem CID

10618