4-Hydroxyquinoline

SKU: orb1221967

Description

4-Hydroxyquinoline is a quinolone compound which forms the core moiety of antibacterials.

Key Properties

• CAS Number: 611-36-9
• MW: 145.16
• Purity: >98% (HPLC)
• Formula: C₉H₇NO
• SMILES: Oc1ccnc2ccccc12
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 100 mg/mL (688.90 mM)

Bioactivity

• In Vitro:
  4-Quinolone (Kynurine) promotes tumor cell survival and motility by suppressing antitumor immune responses through AhR in an autocrine/paracrine fashion. This system is particularly active in human brain tumors where the activation of AhR enhances the expression of TDO producing more kynurine and kynurinic acid. In the healthy human brain, very low levels of TDO exist, whereas, in human brain tumors, the TDO protein levels increase with malignancy.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Hydroxyquinoline | 4 Hydroxyquinoline | Kynurine |

Quick Database Links

Gene Symbol

Antioxidant