4-Butylresorcinol

SKU: orb1300048

Description

4-Butylresorcinol is a potent tyrosinase inhibitor (IC50: 11.27 µM) used as a skin-depigmenting agent in cosmetics. Its efficacy in modulating melanin synthesis is supported by in vitro studies, making it a relevant compound for dermatological research and the development of topical treatments for hyperpigmentation.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 18979-61-8
• MW: 166.22
• Purity: 99.48% (May vary between batches)
• Formula: C₁₀H₁₄O₂
• SMILES: CCCCc1ccc(O)cc1O
• Target: Tyrosinase
• Solubility: DMSO:150 mg/mL (902.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (24.06 mM)

Bioactivity

• Target IC50:
  Tyrosinase:11.27 μM
• In Vitro:
  4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. It is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4Butylresorcinol, 4-Butylresorcinol, 4 Butylresorcinol, Butylresorcinol, Tyrosinase

Compound Identifiers

PubChem CID

205912