3,4-O-Isopropylidene-shikimic acid

SKU: orb1297506

Description

3,4-O-Isopropylidene-shikimic acid is a research compound exhibiting anti-inflammatory, antioxidant, and analgesic properties. Its protective effects, demonstrated in a rat model of trinitrobenzenesulfonic acid-induced colitis, are attributed to its antioxidant activity, supporting research in inflammation and oxidative stress.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 183075-03-8
• MW: 214.22
• Purity: 99.61% (May vary between batches)
• Formula: C₁₀H₁₄O₅
• SMILES: [H][C@]12OC(C)(C)O[C@@]1([H])[C@H](O)CC(=C2)C(O)=O
• Target: NO Synthase,NOS
• Solubility: DMSO:60 mg/mL (280.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.34 mM)

Bioactivity

• In Vitro:
  3,4-O-Isopropylidene shikimic acid (ISA,1-100 micromol/L) effectively reduced PMN adhesion to TNF-alpha-induced HUVEC with the inhibitory rate from 17.2 % to 53.5 % and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-alpha (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,4 O Isopropylidene shikimic acid, 3,4-O-Isopropylidene shikimic acid, 3,4OIsopropylideneshikimic acid, 3,4-O-Isopropylidene-shikimic acid, acid, antioxidant, anti-inflammatory, inhibit, NOSynthase, NOS, NO Synthase, Inhibitor, PGE, shikimic

Compound Identifiers

PubChem CID

25173541