3,3'-Diindolylmethane

SKU: orb1304763

Description

3,3'-Diindolylmethane

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1968-05-4
• MW: 246.31
• Purity: 99.09%
• Formula: C₁₇H₁₄N₂
• SMILES: C(C1=CNC2=C1C=CC=C2)C1=CNC2=C1C=CC=C2
• Target: Androgen Receptor,Autophagy
• Solubility: DMSO:50 mg/mL (203 mM);Ethanol:18 mg/mL (73.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM)

Bioactivity

• In Vivo:
  Preliminary studies show 3,3'-Diindolylmethane is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of 3,3'-Diindolylmethane has radioprotection and mitigation properties in vivo. 3,3'-Diindolylmethane Activates ATM in Normal Tissues. 3,3'-Diindolylmethane can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability.
• In Vitro:
  3,3'-Diindolylmethane is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. 3,3'-Diindolylmethane can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. 3,3'-Diindolylmethane alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity.
• Cell Research:
  The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,3' Diindolylmethane, 3,3'Diindolylmethane, 3,3'-Diindolylmethane, Arundine, Autophagy, Androgen Receptor, AndrogenReceptor, DIM, Inhibitor, inhibit, HB 236, HB236, HB-236

Compound Identifiers

PubChem CID

3071