3-O-Acetyl-11-hydroxy-beta-boswellic acid

SKU: orb1297501

Description

3-O-Acetyl-11-hydroxy-beta-boswellic acid

Research Area

Metabolism Research

Key Properties

• CAS Number: 146019-25-2
• MW: 514.74
• Purity: 98.24%
• Formula: C₃₂H₅₀O₅
• SMILES: [H][C@@]12CC[C@]3(C)[C@]([H])([C@H](O)C=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@]5(C)CC[C@@]34C)[C@@]1(C)CC[C@@H](OC(C)=O)[C@]2(C)C(O)=O
• Target: Lipoxygenase
• Solubility: DMSO:50 mg/mL (97.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.89 mM)

Bioactivity

• In Vitro:
  4 pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and Mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid; 2, 3-O-Acetyl-11-hydroxy-beta-boswellic acid ; 3. 3-O- acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme. It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC50 = 21.1 ± 0.3 μM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-O-Acetyl-11-hydroxy-b-boswellic acid, 3OAcetyl11hydroxybetaboswellic acid, 3-O-Acetyl-11-hydroxy-beta-boswellic acid, 3-O-Acetyl-11-hydroxy-β-boswellic acid, 3 O Acetyl 11 hydroxy beta boswellic acid, 5-Lipoxygenase, Inhibitor, LOX, inhibit, Lipoxygenase

Compound Identifiers

PubChem CID

134715236