3-Isomangostin

SKU: orb1304665

Description

3-Isomangostin is a multi-target small molecule exhibiting potent inhibition of human aldose reductase (IC50 3.48 µM) and MTH1 (IC50 52 nM). It also functions as an acetylcholinesterase inhibitor and free radical scavenger, with demonstrated antiplasmodial and anticancer research applications in vitro.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 19275-46-8
• MW: 410.46
• Purity: 99.90%
• Formula: C₂₄H₂₆O₆
• SMILES: COc1c(O)cc2oc3cc4OC(C)(C)CCc4c(O)c3c(=O)c2c1CC=C(C)C
• Target: MTH1,DNA/RNA Synthesis
• Solubility: Ethanol:40 mg/mL (97.45 mM);DMSO:40 mg/mL (97.45 mM)

Bioactivity

• Target IC50:
  MTH1:52 nM
• In Vitro:
  Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-Isomangostin (17), known from G. mangostana, showed antiplasmodial activity with an IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited an IC50 values in the range of 0.01-0.24 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATPase, Antifection, 3 Isomangostin, 3Isomangostin, 3-Isomangostin, DNA/RNA Synthesis, Inhibitor, inhibit, MTH1, Potassium Channel

Compound Identifiers

PubChem CID

13873655