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3-Hydroxypyridine

SKU: orb1909105

Description

This small molecule inhibitor targets DNA topoisomerase IIβ (Topo IIβ) and demonstrates anti-HIV-1 activity in Sup-T1 cell cultures. It is a useful research tool for investigating viral replication mechanisms and topoisomerase function in both cellular and biochemical assays.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number109-00-2
MW95.1
FormulaC5H5NO
SMILESOC1=CC=CN=C1
TargetOthers
SolubilityDMSO:100 mg/mL (1051.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (42.06 mM)

Bioactivity

Target IC50
MIAPaCa2 cells:56480 nM
In Vitro
Treatment of HaCaT keratinocytes with 3-Hydroxypyridine (100 μM, 3 days) and subsequent exposure to solar-simulated light inhibited proliferation and induced cell cycle arrest and apoptosis.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

3 Hydroxypyridine, 3Hydroxypyridine, 3-Hydroxypyridine

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information