2,4-DPD

SKU: orb1299588

Description

2,4-DPD is a competitive inhibitor targeting HIF-α prolyl hydroxylase (HIF-PH), a key oxygen-sensing enzyme. This small molecule is used in biochemical research to stabilize HIF-α, facilitating studies of hypoxia pathways in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 41438-38-4
• MW: 223.23
• Purity: 99.74% (May vary between batches)
• Formula: C₁₁H₁₃NO₄
• SMILES: CCOC(=O)c1ccnc(c1)C(=O)OCC
• Target: Others,HIF
• Solubility: DMSO:20 mg/mL (89.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.96 mM)

Bioactivity

• In Vitro:
  2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low μM range

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Collagen formation, Chick-embryo calvaria, Diethyl ester, 2,4DPD, 2,4-DPD, 2,4 DPD, Inhibitor, HIF-PH, inhibit, Procollagen, Prolyl hydroxylation

Compound Identifiers

PubChem CID

170509