2-Thiouridine

SKU: orb1694428

Description

2-Thiouridine (s2U) is a thio-modified nucleoside that enhances the stability of U:A base pairs in RNA while reducing U:G wobble pair fidelity. This property makes it a valuable tool for investigating RNA structure-function relationships and for the design of engineered ribonucleic acids in both in vitro and cellular studies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 20235-78-3
• MW: 260.27
• Formula: C₉H₁₂N₂O₅S
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=S)NC(=O)C=C2
• Target: Others
• Solubility: DMSO: 40 mg/mL (153.69 mM), H2O: 8 mg/mL (30.74 mM), Ethanol: 2 mg/mL (7.68 mM), PBS (pH 7.2): 5 mg/mL (19.21 mM), DMF: 10 mg/mL (38.42 mM). Sonication is recommended.

Storage & Handling

• Storage: Powder: -20°C for 3 years. In solvent: -80°C for 1 year.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3036443