2-TEDC

SKU: orb1704745

Description

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (LOX) enzymes with respective IC50 values of 0.09 µM, 0.013 µM, and 0.5 µM. This small molecule is a valuable research tool for studying LOX-mediated pathways in atherosclerosis, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 132465-10-2
• MW: 315.34
• Purity: 99.97% (May vary between batches)
• Formula: C₁₆H₁₃NO₄S
• SMILES: Oc1ccc(\C=C(/C#N)C(=O)OCCc2cccs2)cc1O
• Target: Lipoxygenase
• Solubility: Ethanol:25 mM;DMSO:90 mg/mL (285.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.46 mM)

Bioactivity

• Target IC50:
  15-LOX:0.5 μM|12-LOX:0.013 μM|5-LOX:0.09 μM
• In Vitro:
  2-TEDC exhibits potent inhibition against 5-, 12-, and 15-lipoxygenase, with IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-LOX, 2TEDC, 2-TEDC, 12-LOX, 15 LOX, 2 TEDC

Compound Identifiers

PubChem CID

6069552