2-Iminobiotin

SKU: orb1220537

Description

2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS respectively).

Key Properties

• CAS Number: 13395-35-2
• MW: 243.33
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₇N₃O₂S??
• SMILES: [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=N)N2
• Target: NOS
• Solubility: DMSO:12.5 mg/mL (51.37 mM)

Bioactivity

• In Vitro:
  Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE

Quick Database Links

Gene Symbol

NOS