2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate

SKU: orb3135535

Description

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is the deuterated form of Octinoxate. Octinoxate (Octyl methoxycinnamate) acts as an agonist of thyroid hormone receptors, leading to a reduction in triiodothyronine (T3) and thyroxine (T4) levels, as well as the transcription levels of type II deiodinase (deio2) related genes in Japanese Medaka. Commonly used as a safe ultraviolet (UV) filter in aquatic environments, Octinoxate inhibits CYP1A1 and CYP1B1, and influences hyaluronic acid (HA) metabolism in human keratinocytes through a PI3K pathway-dependent manner. It also exhibits both anti-estrogenic and anti-androgenic effects in vitro and in vivo.

Key Properties

• CAS Number: 2734919-82-3
• MW: 293.42
• Formula: C₁₈H₂₆O₃
• SMILES: C(=C/C(OCC(CCCC)CC)=O)\C1=CC=C(OC([2H])([2H])[2H])C=C1
• Target: Androgen Receptor,Thyroid hormone receptor(THR),Cytochromes P450,Estrogen Receptor/ERR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor,Thyroid hormone receptor(THR),Cytochromes P450,Estrogen Receptor/ERR,Others