2-Deoxy-D-glucose

SKU: orb1226125

Description

2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity.(In Vitro):2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.(In Vivo):2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 154-17-6
• MW: 164.16
• Purity: >98% (HPLC)
• Formula: C₆H₁₂O₅
• SMILES: O=CC[C@H]([C@@H]([C@@H](CO)O)O)O
• Target: glycolysis
• Solubility: Ethanol: 1 mg/mL (6.09 mM)\nDMSO: 32 mg/mL (194.93 mM)\nWater: 32 mg/mL (194.93 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ba 2758 | NSC 15193

Quick Database Links

Gene Symbol

glycolysis