2′-Deoxy-2′-fluoroguanosine

SKU: orb1303701

Description

2′-Deoxy-2′-fluoroguanosine is a potent nucleoside analog inhibitor of influenza A and B virus replication, demonstrating low-micromolar efficacy in vitro. Research applications include studying antiviral mechanisms and in vivo models, where it has shown activity in reducing respiratory tract symptoms.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 78842-13-4
• MW: 285.23
• Purity: 99.82% (May vary between batches)
• Formula: C₁₀H₁₂FN₅O₄
• SMILES: Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
• Target: Influenza Virus|||Nucleoside Antimetabolite/Analog
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.01 mM);DMSO:50 mg/mL (175.3 mM)

Bioactivity

• Target IC50:
  Influenza A and B:<0.35 μM(EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Analog, analog, 2′Deoxy2′fluoroguanosine, 2′-Deoxy-2′-fluoroguanosine, 2′ Deoxy 2′ fluoroguanosine, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Nucleoside Antimetabolite, nucleoside, nasal, InfluenzaVirus, Influenza Virus, influenza, Influenza A and B, inflammation, inhibit, Inhibitor, fever, tract, strains, respiratory, virus, upper

Compound Identifiers

PubChem CID

135415565