2-Acetylbenzoic acid

SKU: orb1297651

Description

2-Acetylbenzoic acid demonstrates superior potency over its propionyloxy analog in suppressing platelet aggregation and platelet prostaglandin synthesis, while both compounds show similar efficacy in inhibiting prostacyclin (PGI2) production. This small molecule is utilized in cardiovascular and thrombosis research to study cyclooxygenase pathways in both in vitro and ex vivo experimental models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 577-56-0
• MW: 164.16
• Purity: 99.62%
• Formula: C₉H₈O₃
• SMILES: CC(=O)C1=C(C=CC=C1)C(O)=O
• Target: Prostaglandin Receptor,PAFR
• Solubility: DMSO:55 mg/mL (335.04 mM)

Bioactivity

• In Vitro:
  A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-Acetylbenzoic acid had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2 Acetylbenzoic acid, 2Acetylbenzoic acid, 2-Acetylbenzoic acid, PGE, ProstaglandinReceptor, Prostaglandin Receptor

Compound Identifiers

PubChem CID

68474