1,7-Diphenyl-4-hepten-3-one

SKU: orb1683993

Description

This small molecule, isolated from Alpinia officinarum, is an Nrf2 pathway activator that suppresses pyroptosis. It has demonstrated efficacy in Alzheimer's disease research, alleviating cognitive deficits and pathology in APP/PS1 mice while protecting HT22 cells from Aβ-induced oxidative stress.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 79559-59-4
• MW: 264.36
• Formula: C₁₉H₂₀O
• SMILES: O=C(C=CCCC=1C=CC=CC1)CCC=2C=CC=CC2
• Target: Nrf2,Pyroptosis

Bioactivity

• In Vivo:
  1,7-Diphenyl-4-hepten-3-one can alleviate AD-like pathology by activating Nrf2 pathway to inhibit pyrodeath.
• In Vitro:
  1,7-Diphenyl-4-hepten-3-one prevents oxidative stress damage and reduces the levels of pyrogenic proteins. 1,7-Diphenyl-4-hepten-3-one improves Aβ-induced proliferation of HT22 cells and reduces the level of pyroxy-associated proteins.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,7 Diphenyl 4 hepten 3 one, 1,7Diphenyl4hepten3one, 1,7-Diphenyl-4-hepten-3-one

Compound Identifiers

PubChem CID

641643