1,4-DPCA

SKU: orb1306255

Description

1,4-DPCA

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 331830-20-7
• MW: 240.21
• Purity: 97.77%
• Formula: C₁₃H₈N₂O₃
• SMILES: OC(=O)C1=CN=C2C(C=Cc3cccnc23)C1=O
• Target: HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:2.78 mg/mL (11.57 mM)

Bioactivity

• In Vivo:
  In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity.
• In Vitro:
  1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

healing, Inhibitor, Hypoxia-inducible factors, HIFs, HIFProlylHydroxylase, HIF ProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF, HIF-1α, HIF-PH, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, FIH, inhibit, 1,4 DPCA, 1,4DPCA, 1,4-DPCA, P4HA1, P4HA2, P4HA3, wound

Compound Identifiers

PubChem CID

71025078