13-Methylberberine chloride

SKU: orb1297518

Description

13-Methylberberine chloride

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 54260-72-9
• MW: 385.84
• Purity: 99.85%
• Formula: C₂₁H₂₀ClNO₄
• SMILES: [Cl-].COc1ccc2c(C)c3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
• Target: Interleukin,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.59 mM);DMSO:10 mg/mL (25.92 mM)

Bioactivity

• In Vitro:
  We screened 11 protoberberine and 2 benzophenanthridine alkaloids for their anti-adipogenic effects on 3T3-L1 adipocytes and found that 13-Methylberberine exhibited the most potent activity. 13-Methylberberine down-regulated the expression of the main adipocyte differentiation transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα±), as well as their target genes. PPARγ, C/EBPα±, and sterol regulatory element binding protein 1 (SREBP-1) protein levels were reduced, and this lipid-reducing effect was attenuated by an AMP-activated protein kinase (AMPK) inhibitor, indicating that the effect of this compound requires the AMPK signaling pathway. Decreased Akt phosphorylation suggested reduced de novo lipid synthesis. C-13 methyl substitution of berberine increased its accumulation in treated cells, suggesting that 13-Methylberberine has improved absorption and higher accumulation compared to berberine.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, Akt, 13Methylberberine chloride, 13-Methylberberine Chloride, 13-Methylberberinium, 13 Methylberberine chloride, PPAR

Compound Identifiers

PubChem CID

148670