11β-HSD1-IN-11

SKU: orb1689806

Description

11β-HSD1-IN-11 is a potent, competitive inhibitor of 11β-hydroxysteroid dehydrogenase 1, exhibiting IC50 values of 0.34 μM in rats and 0.13 μM in humans. This small molecule is a valuable research tool for investigating metabolic disorders, obesity, and inflammation in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 859721-81-6
• MW: 328.31
• Purity: 99.42% (May vary between batches)
• Formula: C₁₅H₁₁F₃O₃S
• SMILES: S(CC(=O)C1=CC=C(C(F)(F)F)C=C1)(=O)(=O)C2=CC=CC=C2
• Target: Dehydrogenase
• Solubility: DMSO:55 mg/mL (167.52 mM)

Bioactivity

• In Vivo:
  A single administration of the 11β-HSD1 inhibitor, Merck 544, significantly decreased the concentration of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in rat liver.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

11β-HSD1-IN-11, 11β-HSD1, 11βHSD1IN11, 11b-HSD1-IN-11, 11beta-HSD1-IN-11

Compound Identifiers

PubChem CID

11232699