1-HEXACOSANOL

SKU: orb1296997

Description

1-HEXACOSANOL

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 506-52-5
• MW: 382.71
• Purity: ≥98% (May vary between batches)
• Formula: C₂₆H₅₄O
• SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCCO
• Target: NPC1L1,AMPK
• Solubility: DMSO:Insoluble

Bioactivity

• In Vivo:
  Plasma, hepatic cholesterol concentrations and hepatic steatosis were significantly reduced in high-fat-fed mice orally administered with hexacosanol (0.7 mg/kg body weight/day) for 8 weeks compared to those of vehicle-fed control mice (-15 and -40%, respectively). Diabetes was induced in 8-week-old male Sprague-Dawley rats by administering an intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into four groups and maintained for 8 weeks: control rats, diabetic rats without treatment with N-hexacosanol, and diabetic rats treated with N-hexacosanol (2 mg/kg and 8 mg/kg i.p. every day). Although N-hexacosanol failed to modify the diabetic status, increases in serum creatinine as well as in kidney weight were significantly reduced. The malonaldehyde and transforming growth factor beta-1 (TGF-beta1) concentrations as well as the protein kinase C (PKC) activities in the diabetic kidney were significantly higher than those of the control, which were decreased by treatment with N-hexacosanol. Histological examinations revealed that N-hexacosanol significantly ameliorated diabetic-induced tubulointerstitial pathological changes.
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Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, 1HEXACOSANOL, 1-HEXACOSANOL, 1 HEXACOSANOL, SREBP2

Compound Identifiers

PubChem CID

68171