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Product Overview
Product Name RAS antibody (ATTO-633)
Catalog Number orb151890
ReactivityHuman, Mouse, Rat
Tested applicationsIHC-P, WB
Immunogen Synthetic peptide corresponding to amino acids 31-43 of human RAS. (The immunogen peptide is from the effector binding loop (l2) of the H, K and N-Ras (AA31-43). This sequence is identical yeast, slime mould, fingi, Xenopus, rat, mouse and chicken over th
Target RAS. Detects 21kDa.
Alternative Names
Product Properties
Form/Appearance PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Storage Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Note For research use only.
Purity Protein G Purified
MW 21 kDa
Uniprot ID B2KGV5
NCBI NP_035067.2
Product Description

Rabbit polyclonal to RAS (ATTO-633). The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTPbound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6)..

Application Notes
Dilution Range WB:1:1000
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