PROTAC AR Degrader-9

SKU: orb2945718

Description

PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 765.339
• Formula: C₄₃H₄₉ClN₆O₅
• SMILES: C1CC(CN(C1)C2=CC=C(C=C2)C(=O)NC3CCC(=O)NC3=O)CN4CCC(CC4)C5=CC=C(C=C5)C(=O)NC6CCC(CC6)OC7=CC(=C(C=C7)C#N)Cl
• Target: PROTACs,Androgen Receptor

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676987