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Product Overview
Product Name KLK6 antibody
Catalog Number orb76280
Species/HostRabbit
ReactivityHuman
ConjugationUnconjugated
Tested applicationsICC, IF, IHC-P, WB
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6(227-244aa YTNVCRYTNWIQKTIQAK).
Target KLK6. Human.No cross reactivity with other proteins.
Alternative Names
Product Properties
Form/Appearance Lyophilized: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Concentration 500 μg/ml
Storage Store at -20°C for one year.After reconstitution, at 4°C.for one month. It can also be aliquotted and stored frozen at -20°C.for a longer time. Avoid repeated freezing and thawing.
Note For research use only.
Isotype Rabbit IgG
ClonalityPolyclonal
Purity Immunogen affinity purified
Uniprot ID Q92876
Product Description

Rabbit Polyclonal to KLK6. KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

Application Notes
Dilution Range IF/ICC: 0.5-1 μg/ml, IHC-P: 0.5-1 μg/ml, WB: 0.1-0.5 μg/ml
Application Notes Experiment Notes: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Validation Images
Western blot analysis of Lane 1: MCF-7 Cell Lysate, Lane 2: HELA Cell Lysate, Lane 3: MM231 Cell Lysate, Lane 4: M453 Cell Lysate, Lane 5: A549 Cell Lysate, Lane 6: SMMC Cell Lysate, Lane 7: COLO320 Cell Lysate, Lane 8: SW620 Cell Lysate, Lane 9: HT1080 C
Western blot analysis of Lane 1: MCF-7 Cell Lysate, Lane 2: HELA Cell Lysate, Lane 3: MM231 Cell Lysate, Lane 4: M453 Cell Lysate, Lane 5: A549 Cell Lysate, Lane 6: SMMC Cell Lysate, Lane 7: COLO320 Cell Lysate, Lane 8: SW620 Cell Lysate, Lane 9: HT1080 C
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