Anti-CLDN6 Reference Antibody (DS-9606a)

• Catalog Number: orb1818472
• Category: Antibodies
• Description: Recombinant Antibody
• Clonality: Monoclonal
• Isotype: IgG1
• Conjugation: Unconjugated
• Reactivity: Human
• Form/Appearance: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.This antibody is purified through a protein A column.
• Concentration: 1mg/ml
• Protein Sequence: CLDN6
• UniProt ID: P56747
• MW: 145.84
• Tested applications: ELISA, FC
• Antibody Type: Primary Antibody
• Expression System: CHO Cell
• Endotoxins: < 0.001EU/μg,determined by LAL method.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: Claudin-6, Skullin, CLDN6
• Note: For research use only

The purity of Anti-CLDN6 Reference Antibody is more than 99.37%, determined by SEC-HPLC.

Immobilized human CLDN6 VLP Protein at 2 µg/mL can bind Anti-CLDN6 Reference Antibody, EC50=0.00407 µg/mL.

DS-9606a by huCLDN6-HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.

Anti-CLDN6 Reference Antibody on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%

DS-9606a inhibited the tumor growth of PA-1 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 84.7% at 5 mpk at D46.

Human CLDN6 CHO cells were stained with Anti-CLDN6 Reference Antibody and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC64=3.036 nM